Endocrine Abstracts

Background: Overshoot of weight regain following the treatment of hyperthyroidism is well described. Notwithstanding, there is a large interindividual variability in the observed weight changes. This study aims to identify parameters predicting excessive weight gain in hyperthyroidism patients.Methods: In a retrospective study of a prospectively completed database, we recruited consecutive patients with overt hyperthyroi...

Metabolic syndrome is characterized by the hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, leading to increased steroidogenesis and altered cortisol secretion. The molecular signaling mechanisms underlying HPA axis alterations in metabolic diseases remain poorly understood. In this study, our objective is to investigate how changes in signaling molecules within both plasma and adipose tissue contribute to the regulation of adrenal steroidogenesis in metabolic...

Background: Androgen excess frequently manifests in pre-pubertal children as premature adrenarche (PA). PA is characterised by the development of pubic and axillary hair, adult-type body odour in girls <8yrs and in boys <9yrs. PA may be a forerunner condition of polycystic ovary syndrome (PCOS), a complex metabolic disorder characterised by androgen excess. It is well established that women with PCOS have high risk of insulin resistance and frequently develop type 2 di...

Background: Thyroglobulin (Tg) is a protein exclusively synthesized by follicular thyroid cells. Serum Tg levels depend on thyroid volume, serum TSH levels, gender, age, smoking, and iodine intake. Consequently, serum Tg reference range may exhibit variations among different populations. It is crucial to establish population-specific reference ranges, especially when interpreting serum Tg values in the follow-up of patients with differentiated thyroid cancer who have undergone...

Introduction/Aim: In this study, we aimed to evaluate the long-term impact of the diabetes awareness day in Greece (in 2016-2023), which is organized every year in November, by examining the relevant local internet searches.Materials/Methods: We collected monthly data with Google Trends, exclusively from Greece, on relevant [online] search volumes (RSVs), with keywords "diabetes" (study group; in medical/scientific and lay terms, in Greek and in ...

Introduction: Hematopoietic stem cell transplantation (HSCT) is the standard of care treatment for high-risk hematological malignancies. HSCT recipients are exposed to chemotherapy and/or radiation prior to HSCT, as part of the conditioning, or following HSCT for management of disease relapse. They may receive steroids for chronic graft-versus-host disease (cGvHD) and they are at high risk for endocrine complications. Aim: To evaluate endocrine complicat...

Introduction: The SARS-CoV-2 virus has severely affected humanity. The disease causes pneumonia which may be severe. In many cases, patients, especially if there are comorbidities, may have a fatal outcome. The disease affects all organs and the variability of its manifestations has attracted intense scientific interest. Aim: The aim of the study was to describe the case of a patient who developed subacute thyroiditis after infection with the SARS-CoV-2 ...

Introduction: Researchers argue that increased morbidity is noted in pregnant women during the current COVID-19 pandemic. Reports indicate that the pandemic has led to disruptions in care of persons with diabetes. Glycated hemoglobin A1c (A1c) is not sufficient in screening for gestational diabetes mellitus (GDM) but may be of use in monitoring glycemia in GDM. To the best of our knowledge no studies honed on late pregnancy glycemia (via A1c), as a surrogate of the access/qual...

Background: Abdominal obesity is associated with insulin resistance and increased cardiometabolic disease risk, whereas lower-body fat accumulation seems protective against metabolic derangements. Differences in upper-body and lower-body adipose tissue (AT) function seem to underlie these opposing associations. Here, we investigated the inflammatory signature of upper- and lower-body AT in women with normal weight and obesity, as well as in human primary abdominal (ABD) and fe...

Introduction: The biological rhythm pattern is synchronized through circadian oscillation of cortisol and melatonin release. Increased cortisol levels and circadian rhythm disruption act as an oncogenic factor in endometrial cancer through among others- dysregulation of cell proliferation/apoptosis and invasion.Aim: To investigate, whether there is an oscillatory expression of the clock genes, MT1 and GR expression in human endometrial carcinoma cells. T...